How Much Liquid Benadryl To Give A Dog? (Perfect answer)

You should give 50 mg of Benadryl to a 50 lb dog, either as two 25 mg tablets, four 12.5 mg chewable tablets, or 20 ml of a Benadryl liquid form (12.5 mg/5 ml).


Can you give liquid Benadryl to dogs?

Avoid the adult formula of liquid Benadryl, as this often contains alcohol, which is toxic to dogs. As with any flavored human medication, always check the inactive ingredients for xylitol, a sweetener that is extremely toxic to dogs. Do not give your pet any medication (or any other substance) containing xylitol.

Can I give my dog 1 ml of Benadryl?

According to the Merck Veterinary Manual, the standard dose for Benadryl is 2-4 milligrams per kilogram of body weight, or 0.9-1.8 milligrams (mg) of Benadryl per pound. Therefore, a simple and practical dose is 1 mg of Benadryl per pound of your dog’s weight, given 2-3 times a day.

How much liquid Benadryl can a 11 pound dog have?

According to the Merck Veterinary Manual, the safe dosage is 2-4 milligrams of medication per kilogram of weight, or 0.9 to 1.8 milligrams per pound. This amount can be administered two to three times daily, depending on your dog’s symptoms.

How many ml of Benadryl can I give my dog per pound?

According to the Merck Veterinary Manual, the safe dosage is 2-4 milligrams of medication per kilogram of weight, or 0.9 to 1.8 milligrams per pound. This amount can be administered two to three times daily, depending on your dog’s symptoms.

How much Benadryl can I give my 80lb dog?

The standard dosage for oral Benadryl for dogs is 1 mg per pound of body weight, given 2-3 times a day.

Is 5mL of Benadryl too much for a dog?

Liquid Formulas According to Veterinary Place, the recommended dosage for these formulas is 0.4 mL/lb. Now, the pediatric Benadryl liquid formula contains 12.5 mg/5mL, which averages out to roughly 2.5 mg/mL. In this scenario, a 25-pound dog would therefore take no more than 10 mL.

How can I relieve my dogs itching?

Oatmeal is an age-old remedy for our dry, itchy skin that happens to be safe for use on our canine friends too! In fact, most doggy hypoallergenic shampoos include oatmeal as an active ingredient to soothe and fight irritation. Start by grinding plain oatmeal into a powder to sprinkle in your dog’s warm bath.

Can I give my dog 50 mg of Benadryl?

Official Answer. The general dose of Benadryl (diphenhydramine) is 2 to 4 mg/kg up to three times day. If your dog weighs 25 lbs (11.3 kg) the dose of Benadryl would be 22.6mg to 45.2mg up to three times a day. Benadryl tablets are available in 25mg and 50mg strength.

Can you give a dog Benadryl for itching?

Benadryl is a great medication for use in dogs with mild-to-moderate allergies. Seasonal allergies, food allergies, environmental allergies, and allergic reactions to snake and insect bites all respond to Benadryl in most cases.

How many 25 mg Benadryl can I give my dog?

Benadryl Dose for Dogs Plumb’s Veterinary Drug Handbook recommends giving a standard dosage of 25 milligrams for a 25-pound dog two to three times per day. As a general rule of thumb, use 1 milligram per pound of your dog’s body weight. For example, a 50-pound dog would be given two 25 milligram tablets.

What is the best antihistamine for dogs?

Benadryl (diphenhydramine) is the most popular antihistamine for humans and can be effective for dogs as well. Just be aware that Benadryl has sedative properties, so your dog could get very drowsy. Other safe antihistamines for dogs include Claritin (loratadine) and Zyrtec (cetirizine).

Benadryl For Dogs: Dosage, Side Effects, And Alternatives

  • Benadryl is also available in liquid form, however it is harmful to dogs due to the presence of alcohol in the formulation. It is thus not recommended that you offer it to your dog. Diphenhydramine 25 mg per tablet: Each Benadryl tablet contains 25 milligrams of Diphenhydramine. Because your dog is likely to despise eating the tablet, you may need to disguise it in a tasty treat each time you provide it. Never use time-release pills in dogs since they are difficult to dose appropriately due to the fact that tablets are absorbed differently in dogs than they are in people. Using the children’s liquid Benadryl is a good option if you want to use a liquid Benadryl because it does not include alcohol. It is also less concentrated and has a smaller dose range, which may make it more suited for owners of tiny dogs because it will be easier to measure out
  • It is also less expensive. Dogs that have difficulty breathing due to swelling caused by bug bites or allergic reactions might benefit from using Benadryl spray in an emergency situation. While spraying Bendaryl on fresh or raw wounds will not hurt your dog, it will sting and cause substantial discomfort for him. Benadoil is also available in gel or cream form, which you may administer straight to your dog’s irritated skin if necessary. Keep in mind, however, that discomfort might arise following continuous usage of the product. If the skin becomes infected, your veterinarian may prescribe an antibiotic for dogs such as Cephalexin. If you are experiencing severe allergic reactions, your veterinarian can prescribe Benadryl through an injection. Muscle, venous, or subcutaneous injections can be used to provide the medication.

How does Benadryl work?

A chemical release of histamine occurs in the body as a result of an allergic response. Histamine, once produced, attaches to receptors on certain cells, producing itching and inflammation in the affected area. H-1 receptors are the name given to these receptors. Benadryl (also known as Diphenhydramine) is an antihistamine that acts by inhibiting the H-1 receptors in the body and so lowering the effects of histamine on the body. It works by inhibiting the signals that are sent to the dog’s vomiting area in the brain when he or she is given Benadryl for motion sickness.

Is Benadryl safe for dogs?

If a dog consumes an excessive amount of Benadryl, he or she may experience symptoms that are potentially life-threatening. Any of these symptoms should be reported to your veterinarian or an emergency veterinary facility as soon as possible.

  • Adverse reactions include: abnormal heart rate, aggressiveness or agitation, constipation, Dog Breathing Issues, dilated pupils, extreme sleepiness, muscle tremors, red eyes, and seizures.

Ironically, Benadryl can trigger an allergic reaction in certain dogs, despite the fact that it is non-toxic. As with any medicine, you should always keep a close eye on your dog after they have used it for the first time.

Dosage of Benadryl

Unfortunately, Benadryl can trigger an allergic response in certain dogs, despite the fact that it is generally safe. Immediately following their initial usage of any medicine, you should keep a watchful eye on your dog.

  • Due to the presence of alcohol in Benadryl in liquid form, as previously stated, it is hazardous to dogs and should not be given to your dog in this form. Children’s liquid formula, on the other hand, is a more safer option. Take a look at the chart below. Sodium Diphenhydramine Tablet:Each Benadryl tablet includes 25 mg of Diphenhydramine (1 tablet for a 25 lb. dog), but always verify the dose on the label and never assume that every product has the same amount. Take a look at the chart below. If you are giving your dog Benadryl, check to be that the medication includes solely Diphenhydramine and is not coupled with other medications like as Tylenol, since this might result in dangerous side effects. Topical:When applying the topical to your dog’s skin, examine a tiny area first to make sure there are no adverse reactions. Always avoid applying gel or lotion to your dog’s skin if the skin is blistered. If you are also feeding your dog Benadryl pills to alleviate the symptoms, it is possible that an overdose will occur. 10 mg/ml and 50 mg/ml concentrations of injectable Benadryl are available for purchase. Based on the symptoms, your veterinarian will calculate the appropriate dosage to be administered.
Max Dose (every 8-12 hours) Max Dose (every 8-12 hours)
Dog Weight Tablet (mg) Children’s Liquid (ml)
1 lbs – 10 lbs 1 mg – 10 mg 0.4 ml – 4 ml
10 lbs – 20 lbs 10 mg – 20 mg 4 ml – 8 ml
20 lbs – 30 lbs 20 mg – 30 mg 8 ml – 12 ml
30 lbs – 40 lbs 30 mg – 40 mg 12 ml – 16 ml
40 lbs – 50 lbs 40 mg – 50 mg 16 ml – 20 ml
50 lbs – 60 lbs 50 mg – 60 mg 20 ml – 24 ml
60 lbs – 70 lbs 60 mg – 70 mg 24 ml – 28 ml
70 lbs – 80 lbs 70 mg – 80 mg 28 ml – 32 ml
80 lbs – 90 lbs 80 mg – 90 mg 32 ml – 36 ml
90 lb – 100 lbs 90 mg – 100 mg 32 ml – 36 ml
100 lbs – 110 lbs 100 mg – 110 mg 40 ml – 44 ml
110 lbs – 120 lbs 110 mg – 120 mg 44 ml – 48 ml
120 lbs – 130 lbs 120 mg – 130 mg 48 ml – 52 ml
130 lbs – 140 lbs 130 mg – 140 mg 52 ml – 56 ml
140 lbs – 150 lbs 140 mg – 150 mg 56 ml – 60 ml

How long does it take for Benadryl to work in dogs?

It normally takes 24 hours for Benadryl to wear off and cease to be effective in the body. The effects, on the other hand, might linger for a longer period of time in dogs suffering from liver or renal illness. Always consult your veterinarian before administering Benadryl to your dog, especially if your dog suffers from chronic liver, renal, or heart disease.

Side effects of Benadryl

The negative effects of Benadryl in dogs are quite similar to those in people. Dry mouth, drowsiness, and urinary retention are all common adverse effects of this medication. Some dogs may develop unusual adverse effects such as diarrhea, vomiting, fast breathing, elevated heart rate, and changes in their appetite as a result of the medication. If you see any of these symptoms becoming serious, you should contact your veterinarian. Dogs suffering from the following disorders should not be given Benadryl without first visiting their veterinarian: :

  • Allergic pulmonary illness
  • Blockage of the bladder neck Pregnancy or breastfeeding
  • Cardiac disorders (such as cardiovascular disease and heart failure)
  • Glaucoma, high blood pressure, and other conditions Hypertension, hyperthyroidism, low blood pressure, prostatic hypertrophy, and seizure disorders are all conditions that can be treated.

How does Benadryl interact with other drugs?

Benadryl has been shown to decrease the efficiency of prokinetic medicines (metoclopramide and cisapride), which are used to treat constipation and other gastrointestinal issues.

Natural Alternatives to Benadryl

  • Allergies:Benadryl is a brand name for a type of medication known as Diphenhydramine, which is an antihistamine used to relieve the symptoms of allergies, such as rashes, itching, and dog eye allergies, which can be caused by seasonal or environmental allergens
  • Benadryl is also used to treat asthma. In the case of anxiety, the medication Benadryl provides relaxing characteristics that can help dogs remain calm in high-stress circumstances (for example, fireworks and thunderstorms). Insomnia: Benadryl can help dogs who are having difficulty sleeping by making them feel tired and promoting slumber. When it comes to bug bites and bee stings, diphenhydramine can help to alleviate the itching and reduce the severity of the response. During travel, Benadryl can be beneficial in treating nausea and motion sickness due to its similarity to the active component contained in Dramamine (a motion sickness medication)
  • Hence, Benadryl can be used to treat nausea and motion sickness during travel.
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Benadryl for Dogs: Dosage, Side Effects, & Uses

Reaching into our medicine cabinets to treat our dogs is a deadly temptation that should be avoided at all costs. Humans and dogs react to drugs in very different ways, which is why doctors advise dog owners against making autonomous judgments about how to treat their pets. Some human pharmaceuticals, on the other hand, are safe for use with dogs if they are administered in the proper manner. Diphenhydramine, often known by the trade name Benadryl, is prescribed by veterinarians on a daily basis for the treatment of allergies, travel anxiety, and motion sickness in canines.

As usual, check your veterinarian before administering any human medication to your dog. Here are some general guidelines for administering Benadryl to dogs.

What Is Benadryl?

Benadryl is the brand name for the active component diphenhydramine HCl, which is used in many over-the-counter medications. Diphenhydramine is a first-generation ethanolamine-derivative antihistamine, which is the scientific term for antihistamines that can cross the blood-brain barrier, making them extremely effective while also increasing the risk of adverse side effects. Diphenhydramine is used to treat allergies and other allergic reactions. In spite of the fact that Benadryl is not yet FDA-approved for veterinary usage, it is widely utilized in veterinary offices across the United States since it is deemed safe for dogs and cats.

Many of the symptoms linked with allergies, such as itching, sneezing, and hives, are alleviated as a result.

What Does Benadryl Treat in Dogs?

If your dog suffers from mild-to-moderate allergies, Benadryl is an excellent drug to utilize. Seasonal allergies, food allergies, environmental allergies, and allergic responses to snake and bug bites are all treated well with Benadryl in the vast majority of instances, according to the manufacturer. When it comes to treating itchy dogs caused by skin allergies, Benadryl is a popular choice since it helps to alleviate many of the other symptoms of allergies, including:

  • Hives, swelling and inflammation, redness, runny nose and eyes, coughing, sneezing, and anaphylactic response are all possible symptoms.

Drowsiness is one of the adverse effects of Benadryl, which can be beneficial in calming stressed dogs. According to the Merck Veterinary Manual, diphenhydramine may be used to alleviate the symptoms of mild-to-moderate anxiety in dogs that are linked with travel. It may also be beneficial in the treatment of motion sickness. Although Benadryl may temporarily alleviate nervousness in certain animals, it is recommended to consult with your veterinarian or an animal behaviorist to discover and address the underlying cause of the anxiety.

As a precautionary measure during heartworm treatment, veterinarians may give diphenhydramine, which can help lessen the chance of an adverse reaction to the heartworm treatment therapy.

When to Ask Your Vet About Benadryl for Dogs

Before you go for the Benadryl, speak with your veterinarian about the symptoms your dog is experiencing. Itching and red eyes, which are common allergy symptoms, can also be indicators of more severe illnesses. Occasionally, administering Benadryl to your dog may actually aggravate his or her illness. An allergy-related reaction such as red, watery eyes may occur, or it may be an indication of glaucoma or dry eye, which Benadryl will not help to alleviate in any way.

The itching that is commonly connected with allergies and other skin diseases is a good example. In addition, your veterinarian will be able to inform you whether Benadryl will interact with any other drugs that your dog is already on.

Side Effects of Benadryl

It is important for all dog owners to be informed of the potential adverse effects of administering Benadryl to their pets. The majority of negative effects manifest themselves during the first hour of exposure, so keep a close eye on your dog during this period. If your dog suffers from any of the illnesses listed below, you should only provide Benadryl after checking with your veterinarian:

  • Glaucoma, cardiovascular illness, hypothyroidism, seizure disorders, hypertension, allergic lung disease, and pregnancy are among conditions that can occur.

The following are some of the most common negative effects related with the administration of Benadryl to dogs:

  • Drowsiness, dry mouth, urinary retention, hypersalivation, increased heart rate, rapid breathing are all common side effects.

The following are examples of rare side effects:

  • Symptoms include: diarrhea, vomiting, decreased appetite, increased hunger, and nausea.

Benadryl Overdose

Benadryl has the potential to cause an overdose. Hyperexcitability of the central nervous system is one of the signs of an overdose, which can be lethal. Other warning signals to be on the lookout for are:

  • Emotional agitation, constipation, and seizures are all symptoms of hypertension.

Contact your veterinarian or an emergency veterinary facility immediately if you fear your dog has overdosed on Benadryl. Some dogs are allergic to Benadryl, which can cause an allergic response. If your dog begins to show signs of an allergic reaction, take him to the veterinarian as soon as possible.

Dosage of Benadryl for Dogs

Contact your veterinarian or an emergency veterinary facility immediately if you believe your dog has overdosed on Benadryl. Some dogs are allergic to Benadryl, and this might cause them to become sick. Consult your veterinarian as soon as your dog begins to exhibit signs of an allergic reaction.

Is Benadryl Safe for Your Dog?

When administered in accordance with a veterinarian’s instructions, Benadryl is a generally safe and effective medicine for dogs with allergies. Always keep a watchful eye on your dog after administering a new drug to ensure that there are no negative responses to the prescription. If you have any more questions regarding Benadryl for dogs, you should speak with your veterinarian for further information about the medication. Please keep any medications out of reach from your curious canine companion.

Can I Give My Dog Benadryl?

With their natural curiosity and energy, it is inevitable that some dogs may find themselves in predicaments that are difficult to escape. There are a variety of issues that can cause your dog to become itchy, unpleasant, and bloated as a result of an allergic response. These include everything from running through poison ivy to being stung by a bee. Your dog, on the other hand, does not have to suffer. Under the supervision of a veterinarian, you can provide diphenhydramine (Benadryl) to your pet to alleviate the worst of their allergy symptoms.

  1. Both people and animals can benefit from the use of Benadryl, also known as diphenhydramine, which is an antihistamine that can help ease the symptoms of allergies.
  2. The recommended dosage of Benadryl is entirely safe for the vast majority of dogs.
  3. Because the majority of Benadryl pills are designed for human consumption, it is critical to get the dosage properly.
  4. Dogs also metabolize Benadryl in a different way than humans, so it’s not a good idea to base dose recommendations on human guidelines.
  5. The right dosage of diphenhydramine for dogs is determined by the weight of the animal.
  6. As recommended by the Merck Veterinary Manual, a safe dosage is between 2-4 milligrams of medicine per kilogram of body weight, or between 0.93 and 1.8 milligrams per pound of body weight.

While it is preferable to use Benadryl pills or ointments that have been approved by a veterinarian, it is possible to utilize Benadryl tablets designed for people in specific situations. If you decide to go forward with it, bear the following points in mind:

  • First and foremost, never give your dog drugs that have decongestants or alcohol in the formulation. Only provide them drugs that include diphenhydramine as the active component and nothing else. Decongestants and alcohol might be harmful to your dog’s health. Second, dogs should never be given medication in the form of time-released capsules. Your dog’s stomach functions differently from yours, and a capsule that works fine for people may cause your dog to overdose on medication. Aside from that, if they bite the capsule, they may receive the complete amount at once rather than having it distributed over time. Third, it is possible that using children’s Benadryl rather than adult Benadryl is preferable for tiny dogs. This allows you to be more precise in your dosage adjustments. Finally, if you want to administer liquid Benadryl medicine to your dog rather than pills, consult with your dog’s veterinarian to ensure that you are administering the proper amount. Because liquid medicine is absorbed differently than solid medication, the 2-4 milligrams per kilogram rule may not be applicable in this case.


Benadryl has a number of risks for pets. While the correct amount of Benadryl is generally safe for dogs, it is possible that a dog will have an allergic reaction to the medicine itself. An allergy to diphenhydramine will manifest itself with symptoms that are similar to those of other allergies, such as:

  • Bruising and swelling of the cheeks and mouth
  • Red rashes on the skin Symptoms include diarrhea, vomiting, and an upset stomach. The act of gnawing or licking one’s skin

Almost many of the symptoms associated with medicine will manifest themselves within the first hour of ingesting the chemical, so keep an eye out for any changes in your dog’s behavior during this time. There are also a variety of more typical, less harmful adverse effects that dogs may encounter when taking Benadryl, including:

  • Sleepiness, dry mouth, rapid breathing, hypersalivation, and an increased heart rate are all symptoms of hypoxia.

As the drug exits their system, the lesser symptoms will begin to disappear as well. Overdose on Benadryl. Ignoring any of these recommendations can result in an overdose of diphenhydramine, which can cause symptoms ranging from seizures to respiratory failure to coma, depending on the severity of the dosage received. Contact your veterinarian as soon as possible if you feel your dog has overdosed on Benadryl and follow their recommendations for emergency care.

Allergy Relief Without Benadryl

Benadryl alternatives for dogs are available. If your dog has a negative reaction to Benadryl yet requires frequent allergy medication due to a seasonal allergy, there are some alternatives you can try instead. Both cetirizine (Zyrtec) and loratadine (Claritin) are deemed to be safe for dogs when administered in the recommended dosage. They are, however, commonly coupled with other drugs, such as decongestants, which might be harmful to your dog’s health. Always contact with your veterinarian before administering any new medicine to your dog.

These therapies begin to act within minutes of being administered.

When to contact your veterinarian.

Your dog may go into anaphylactic shock as a result of their allergies, or, in rare situations, as a result of taking Benadryl.

  • Seizures
  • Vomiting
  • Diarrhea
  • Swelling
  • Difficulty breathing
  • Etc.

These might be indicators of a significant allergic reaction that need rapid medical attention. As an example, if your dog has been bitten by a snake or stung by an uncommon bug, call your veterinarian immediately to confirm that your dog has not been poisoned by the reptile or insect.

Benadryl For Dogs: Dosage, Side Effects and More

Benadryl is an over-the-counter medication that may be given to dogs to relieve their itching. It is a H 1antagonist, which means that it helps to block the absorption of histamine (a type of chemical responsible for allergic responses) by receptors in the body. Diphenhydramine is the most common active component and is used to treat allergies. This helps to alleviate inflammation, watery eyes, and a variety of other allergy-related symptoms. Additionally, it has the potential to alleviate anxiety and motion sickness through other processes, as well as lessen coughing – although this is an uncommon application.

For this reason, diphenhydramine is the active component in several popular sleeping aids like as Nytol.

If you’re using a prescription dog medication, be sure it only contains active substances that are suitable for canines, such as diphenhydramine or cetirizine.

Natural Remedies include the following: Natural therapies have been shown to be effective in alleviating symptoms in dogs, according to many individuals.

There are no adverse effects and it is safe for dogs of all ages to use. Derma-Ionx– Derma-Ionx is a non-invasive treatment for skin irritation (including allergic diseases) and itching in dogs of any age that has no negative effects.

Recommended Dosage

Please keep in mind that the following recommended dose is for Benadryl formulations that include solely diphenhydramine as the active component. The typical Benadryl dose for dogs is 1 mg/lb every 8 to 12 hours, administered every 8 to 12 hours (two to three times daily). In some circumstances (for example, following a snake bite), 2 mg/lb per dosage may be administered instead. When treating allergies, it is preferable if the medication is administered before to exposure to the allergen. It is important to consult your veterinarian before administering any medication to a dog, as the appropriate dose might vary depending on a variety of circumstances, including your dog’s medical history.

  • Using the children’s formula for treating a tiny dog is preferable since it includes lower amounts of the active ingredient, making it easier to measure out an exact dose.
  • The following is the dog’s weight in pounds: Dosage in milligrams (mg): When taken on a long-term basis (as is commonly the case when treating allergies), Benadryl’s potency might wane.
  • Cetirizine, loratadine, and chlorpheniramine are just a few examples of typical antihistamines that are effective in treating allergies and other conditions.
  • Because of the difficulty in administering medications by this route, the dose is generally between 0.25 and 0.9 mg/lb of body weight.
  • When diphenhydramine is taken orally, it takes around 30 minutes for it to begin functioning.
  • When using liquid, be sure to use the children’s liquid formulation of Benadryl (ideally the dye-free type).
  • Every 5 mL of liquid contains 12.5 mg of diphenhydramine at the usual concentration, and the medication can be administered at a rate of 0.4 mL/lb.
  • When dispensing bigger volumes of medication, a syringe can help you achieve more precision while also making things more convenient.
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To get the average dose for your dog, please use the calculator below: The following is the dog’s weight in pounds: Dosage in milliliters (mL): For example, certain formulations may call for a concentration of 6.25 mg per 5 mL, which means you will need to take double the amount of medication you would normally use.

  • These products typically contain 1 percent diphenhydramine (or 2 percent in the high strength recipe) and can be administered topically 2–3 times per day, depending on the product.
  • Often, while using topical remedies, individuals forget that they are taking medication.
  • If you have also given your dog Benadryl pills or liquid, or any other antihistamine medicines, the risks can quickly mount up and become dangerous.
  • The gels and creams are frequently applied up to three times a day, although the shampoos and conditioners are typically administered once or twice a week, depending on the product.
  • Keep in mind that topical medications can occasionally produce irritation or sensitivity at the application site(s), particularly if used for an extended period of time.
  • Keep dogs away from Benadryl “Itch Cooling Gel,” which includes camphor, because this ingredient is toxic to them.
  • Active Substances Other Than Diphenhydramine:Some Benadryl medications contain active ingredients other than diphenhydramine.

The use of cetirizine-containing formulations in the treatment of dermatitis has been approved by the Food and Drug Administration. The following is a typical daily dose for this medication:

Weight of dog Dosage of cetirizine
0 – 15 lbs 5 mg (½ tablet)
16 – 39 lbs 10 mg (1 tablet)
40 lbs + 15 mg (1½ tablets)

According to one research, a once-daily dose of 0.45 mg/lb (1 mg/kg) was adequate to reduce itching in 18 percent of the dogs that received the medication. The fact that cetirizine seldom induces drowsiness means that it is not as helpful at avoiding anxiety during thunderstorms, fireworks, or other stressful situations. Formulations containing acrivastine may also contain pseudoephedrine, which can be toxic in large dosages. Acrivastine As a result, items containing acrivastine should be avoided wherever possible.

Can I Give My Dog Benadryl?

When it comes to administering Benadryl to dogs, the most widely prescribed formulation (and the one that the majority of people are acquainted with) comprises diphenhydramine. It is important to avoid the use of liquid combinations that include substances that are harmful to dogs’ health. For example, xylitol is a popular addition that, when consumed in big quantities, can be hazardous to dogs. It is also vital to avoid formulas that include a significant level of alcohol. It is devoid of both alcohol and xylitol when it comes to the Benadryl liquid combination for children.

Make certain you only use formulations that contain these substances (remember, the active ingredients will be displayed clearly on the packaging).

Despite the fact that it has not yet been authorized by the FDA for use in animals, it is extremely routinely used in veterinary practice and is generally considered safe for treating dogs at the 1 mg/lb dosage indicated before.

  • Angle-closure glaucoma, COPD (Chronic Obstructive Pulmonary Disease), and other conditions. Enlarged prostate
  • Heart disease
  • High blood pressure
  • Hyperthyroidism
  • Seizures
  • Obstruction of the urinary or gastrointestinal tract

CetirizineCetirizine is a medication that veterinarians may give for the treatment of itching. The fact that cetirizine does not penetrate the blood-brain barrier in substantial quantities means that there are fewer negative effects in general (including less chance of drowsiness). Dogs suffering from renal or liver problems, on the other hand, are at a higher risk of developing complications.

Guidelines For Use

Always speak with your veterinarian before administering medication to your pet, and avoid administering time-release capsules designed for people to your pet. Because of the architecture of a dog, when these capsules are ingested whole, they are not normally completely digested. Make sure to provide your veterinarian the following information so that they can determine whether or not your pet is a candidate for treatment:

  • A list of any additional medications that your dog is now taking
  • Any medical issues that your pet may be experiencing
  • Formulations containing both diphenhydramine and chemicals that are harmful to dogs (such as Tylenol) should not be used.

It is best not to combine this medication with other anticholinergic medications (such as tricyclic antidepressants), since this may cause signs of toxicity. When diphenhydramine is used with depressants, the sedation is likely to be more greater. In addition, there are a few additional medications that potentially interact with diphenhydramine. Pregnancy Nursing Warning:Diphenhydramine is not indicated for usage during pregnancy (particularly when the animal is near term), however your veterinarian may advise you otherwise in some instances, such as when the animal is close term.

Because the medicine is excreted in the milk of nursing dogs, it should be avoided or administered with caution in these animals, especially in puppies.

What Are the Uses of Benadryl for Dogs?

There are various essential applications for Benadryl for dogs, the most popular of which are the treatment of allergies and insect stings. However, the active component determines the range of permissible applications. The next section contains a list of the applications for each individual dog-safe active component. Diphenhydramine:

  • Allergies and reactions to vaccinations
  • Histamine is a sort of chemical that has a function in allergic reactions and other immune system responses. In response to an allergen, the body produces histamine, which is subsequently recognized by receptors throughout the body, resulting in a variety of terrible allergy symptoms. It is possible to avoid the symptoms of allergies by assisting in the prevention of histamine receptors from picking up on it. When it comes to insomnia, diphenhydramine is effective because it not only inhibits the absorption of histamine, but it also helps to inhibit the uptake of another neurotransmitter known as acetylcholine. This is what is causing the tiredness, according to the experts. If the medication is taken on a regular basis, the effectiveness of the medication in encouraging sleep may be diminished. Melatonin is the hormone that is most usually employed for this purpose. Vomiting and motion nausea are common symptoms of pregnancy. Diphenhydramine is chemically extremely similar to dimenhydrinate, which is the active component in the antihistamine Dramamine. In certain cases, it might assist to reduce nausea and motion sickness when traveling. Stings and bites
  • Stings or bites from some species, such as bees, can also cause histamine to be released. It is possible to alleviate pain and swelling by taking an antihistamine such as diphenhydramine. However, if a dog is extremely susceptible to the venom, it is possible that the airway will get restricted. Attempting to administer medications orally to him at this stage might be harmful. Contains further information regarding treating stings with Benadryl, as well as a few home cures that you may try
  • Written by Dr. Jason Nicholas. Anxiety (for example, during July Fourth fireworks)
  • The sedative characteristics of the medication might assist a dog in remaining calm during situations that would normally make him apprehensive, such as during fireworks or trips to the veterinarian. When it comes to treating dermatitis-related itching, diphenhydramine can be beneficial, although cetirizine and glucocorticoids, such as cortisone, are more commonly utilized. However, when used topically, the medication possesses mild anesthetic qualities that might aid in the reduction of itching. Treatment for mast cell tumors is not intended to treat the tumors, but rather to mitigate the potentially harmful side effects associated with an elevated release of histamine in the body. This aids in the management of blood pressure and the decrease of appetite.

If you are unsure whether or not this medication is the best decision for your pet, your veterinarian can explore other options with you. You can also inquire about the usage ofClaritin and chlorpheniramine, two more medications that are widely used to treat allergies. You might also tryDramamine in combination with dimenhydrinate if you are experiencing motion nausea. When it comes down to it, dimenhydrinate is essentially the same exact ingredient as diphenhydramine, except that it is combined with a moderate stimulant to help prevent drowsiness while still delivering efficient nausea treatment.

Side Effects

When taking diphenhydramine, sleepiness is fairly prevalent, however it can be reduced over time with sustained usage of the medication. When dogs are given diphenhydramine, they may encounter a variety of negative side effects. In addition to acting oddly or appearing “spaced out,” individuals may also have the following symptoms:Common symptoms:

  • Sleepiness, dry mouth, urinary retention, and sluggish responses are all common side effects.

Less Frequently Occurring

  • Diarrhea, vomiting, loss of appetite, allergic response, and excitement are all possible symptoms.

With sustained usage of diphenhydramine, the sleepiness that is linked with it may lessen with time. But because of the potential for negative effects on the performance of working dogs, it is not a good choice for this purpose. It has been shown to generate paradoxical exhilaration in rare instances. When given to dogs, cetirizine may cause them to vomit or salivate excessively, but because it does not penetrate the blood-brain barrier as quickly as other medications, undesired side effects such as sleepiness should be avoided.

  • Keep an eye out for classic allergy symptoms such as itching, trouble breathing, rashes, hives, fast heartbeat, and sneezing, amongst other things.
  • Overdose: Although using diphenhydramine for allergies, anxiety, and a number of other ailments is generally considered safe, taking too much of it can be deadly.
  • Muscle tremors, a fast or irregular pulse, breathing difficulty, excessive exhaustion, disorientation, and a high fever are all possible side effects of taking too much medication.
  • If you suspect an overdose, call 911 immediately.
  • If you have not been taught to do so by a professional, do not attempt to make your dog vomit on your own initiative.
  • Aside from causing vomiting (if the dog is stable), other therapeutic options for overdose include the administration of activated charcoal, the administration of physostigmine (a medication that is often used to treat anticholinergic toxicity), and intravenous lipids.

Between 2008 and 2013, a total of 621 dogs were reported to have suffered from an overdose of diphenhydramine; just three of these cases were fatal, according to the data.

More Information

View this informative video by Dr. Greg Martinez, which offers valuable information on administering Benadryl to dogs and how it may be used to treat allergies: Benadryl for Dogs and Cats. Sources Dr. H. PeikesPlumb’s Veterinary Drug Handbook is a resource for veterinarians (sixth edition)

Can You Give a Dog Benadryl?

Benadryl (diphenhydramine) is an over-the-counter drug that is completely safe to provide to your dog. Learn about the proper dose, usage, and side effects of this medication. Diphenhydramine, better known by the brand name Benadryl, is an antihistamine that works by blocking the H1 receptors in the body’s cells. In spite of the fact that drug chemistry may not be your favorite pastime, good old Benadryl may come to the rescue for your dog in a handful of circumstances. Is it possible to feed a dog Benadryl?

Can You Give a Dog Benadryl for Itching?

Yes, it is possible! Benadryl is given to dogs for a variety of reasons, the most prevalent of which include bug bite responses and environmental allergies. Benadryl can also be beneficial for those who are anxious about events such as thunderstorms or fireworks, as well as for people who are experiencing motion sickness or who are being treated for mast cell tumors. As a precaution, if your dog contracts heartworms (don’t forget to give him his monthly preventive! ), Benadryl may be given to help reduce the risk of reactions to the treatment.

It’s impossible to anticipate severe bug bites, but if your dog suffers from seasonal allergies, you may begin administering Benadryl at the time of year when she is most likely to have symptoms.

If your dog is experiencing thunderstorm anxiety or motion sickness, administer the Benadryl about half an hour to an hour before the event.

How Much Benadryl Can You Give a Dog?

Fortunately, diphenhydramine has a quite broad margin of safety in dogs when administered subcutaneously. The recommended dosage is 1 mg per pound of body weight, which is both safe and simple to remember. In the case of a 50-pound dog, the dosage would be 50 mg of Benadryl. Brand-name and generic medications are often available in 25-milligram tablets, which means that a 50-pound dog would receive two pills at a time. Alternatively, if your dog’s weight is between two multiples of 25, you can break the tablets in half to obtain the appropriate dosage.

If possible, avoid using the adult-strength liquid Benadryl since it typically contains alcohol, which is hazardous to dogs.

Always check the inactive components of flavored human medications for xylitol, a sweetener that is particularly poisonous to dogs, just as you would with any other flavored human prescription. Any prescription (or other substance) containing xylitol should not be given to your dog or cat.

How Often Can You Give a Dog Benadryl?

Benadryl is most typically used two or three times each day, depending on the individual.

Can You Give Benadryl Without Talking To Your Vet First?

It’s always a good idea to contact with your veterinarian before administering any medication or supplement to your animal. Making sure it is appropriate for your dog’s symptoms, that you are administering the correct amount, and that it will not conflict with other drugs your dog is receiving are all important considerations. However, as long as you are aware of your dog’s current weight and have double-checked your arithmetic on the 1-milligram-per-pound dosage, you can proceed to administer Benadryl when you notice your dog’s face swelling up as a result of a bug bite.

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If the symptoms persist despite the administration of Benadryl, call your veterinarian.

If you find yourself administering Benadryl to your dog on a frequent basis, talk to your veterinarian about the symptoms you’re seeing and how often you’re giving it to him.

What Is the Best Way to Give Benadryl?

With or without meals, Benadryl can be administered to patients. If your dog drools excessively or vomits after being given Benadryl without food, give it Benadryl with some food the next time you give it Benadryl without food.

What Are the Side Effects of Benadryl in Dogs?

The following are examples of possible negative effects:

  • Drowsiness (which may diminish with time if Benadryl is used on a regular basis)
  • Excessive drooling, dry mouth, and an elevated heart rate Retention of urine in the bladder
  • Diarrhoea, vomiting, and a loss of appetite are less frequent symptoms.

It is possible for a dog to receive an excessive amount of Benadryl. You should immediately contact your veterinarian or a pet poison control center if you find your dog with an open bottle of Benadryl to find out what to do. If the tablets have only recently been ingested, inducing vomiting is generally beneficial in reducing nausea. The following are signs of a Benadryl overdose:

  • Agitation, constipation, dilated pupils, and other symptoms Seizures
  • Slow, shallow, or interrupted breathing
  • Rapid heart rate
  • Seizures

What Are Some Alternatives To Benadryl?

Cetirizine (Zyrtec) and loratadine (Aleve) are two more over-the-counter drugs that may be administered to dogs to alleviate allergy symptoms (Claritin). It is also possible that the supplement quercetin would be beneficial, however there has been limited study to identify the ideal dosage. Benadryl is a highly safe alternative for treating sudden-onset and intermittent allergies, and it may also be beneficial for treating a variety of other illnesses. It’s worth having a talk with your veterinarian if your dog has persistent concerns that need the use of Benadryl to determine whether there is an alternative drug or therapy that can address the underlying cause of your dog’s signs and symptoms.

How Much Benadryl Can I Give My Dog? A Guide to Dosage and Alternatives

The following is a table of contents: It’s pretty usual for dogs to suffer from allergic reactions. A number of dog breeds, including Chinese Shar-Peis, Wirehaired Fox Terriers, Golden Retrievers, Dalmatians, Boxers, and Boston Terriers, among others, are prone to developing allergies, including those listed below. However, every dog breed is susceptible to having an adverse response to anything. When this occurs, it is critical for dog parents to understand how to treat it naturally or, if necessary, with Benadryl.

After all, dogs might be allergic to the same allergens that people are.

This article will go through how to calculate Benadryl dose for dogs, what it is used for, and any potential side effects that may occur as a result.

We’ll also go over several natural options that may be effective in alleviating your dog’s itching, sneezing, runny nose, rash, or other allergy related symptoms.

What Does Benadryl Do?

Benadoil is an over-the-counter antihistamine that goes by the generic name of diphenhydramine HCL (diphenhydramine hydrochloride) (this is also its active ingredient). In both you and your dog, Benadryl can help to decrease allergy symptoms that are caused by a variety of factors such as seasonal allergies, environmental allergies, food allergies, and insect bites. Itching of the skin is the most prevalent symptom of a dog suffering from an allergy, according to Catherine Barnette, DVM, and Ernest Ward, DVM, both from VCA Hospitals.

“In certain cases, the symptoms concern the respiratory system, with coughing, sneezing, and/or wheezing being the most noticeable.” Both the brand-name Benadryl and other diphenhydramine drugs are commonly available in tablets containing 25 milligrams of active ingredient.

Benadryl Dose for Dogs

According to Plumb’s Veterinary Drug Handbook, a normal dosage of 25 milligrams for a 25-pound dog should be administered two to three times per day. As a general rule of thumb, use 1 mg per pound of your dog’s body weight when calculating the amount of medication to provide. For example, two 25 mg pills would be given to a 50-pound dog to help him lose weight. Small dogs weighing less than 25 pounds can be given liquid Benadryl intended for children. A normal quantity of children’s Benadryl, according to, comprises 12.5 milligrams of diphenhydramine in every 5 milliliters of liquid, which may be administered at a dose of 0.44 milliliters per pound.

  1. In particular, if your dog is on any other drugs or has any previous medical issues, this is crucial.
  2. In such circumstances, the veterinarian may need to inject the medication straight into the dog’s skin so that it may begin working immediately to alleviate the symptoms.
  3. Always consult your veterinarian before administering any new drugs, since improper administration (or overuse of the substance) can result in lethal diphenhydramine toxicity.
  4. If you feel your dog is suffering from a Benadryl overdose, contact your veterinarian immediately or call the Pet Poison Helpline at 855-764-7661 for assistance.

Side Effects of Benadryl

Is it possible for Benadryl to make my dog sleepy? It’s possible, to be sure. Benadryl, like most over-the-counter drugs, has the potential to cause negative effects in some people. Drowsiness, dry mouth, hypersalivation, elevated heart rate, trouble breathing, high blood pressure, sedation, urine retention, and loss of appetite are all common adverse effects of this medication.

Consult your veterinarian before administering Benadryl to your pet to ensure that you are administering the right amount and avoiding any potential unpleasant effects.

Benadryl and Dog Anxiety

We’ve answered the question, “How much Benadryl can I give my dog?” and “How much Benadryl should I give my dog?” “Can I feed my dog Benadryl for allergies?” and “Does my dog have allergies?” However, there are certain additional situations in which diphenhydramine HCL is prescribed for dogs. Here’s all you need to know about the situation. Because of its drowsiness-inducing side effect, some pet parents use Benadryl as a light sedative for anxious dogs when confronted with stressful situations such as vet appointments, vehicle rides, fireworks, and thunderstorms.

If you have a dog that suffers from anxiety, you might want to try giving him a natural soothing supplement.

Look for a dog supplement that has active elements that are relaxing to the dog’s system, such as chamomile, ginger root, passion flower, or hemp oil.

Natural Alternatives to Benadryl

For those who are uncomfortable giving their dog Benadryl to alleviate the symptoms of seasonal or environmental allergies, bug bites, hives, or general itching, there are a few natural options you may consider.


Environmental, food, skin, and seasonal allergies are all supported by a variety of natural allergy support supplements that help to maintain your dog’s overall health and immune system while also providing them with assistance with their allergies. These types of supplements contain a component known as colostrum, which is an antibody-rich fluid produced by the mammary glands and found in breast milk. According to VCA Hospitals’ DVMs Steve Marsden, Shawn Messonnier, and Cheryl Yuill, this pre-milk superfood not only helps with allergies, but it can also aid with dental issues like as gingivitis, as well as food intolerances.

Many allergy support supplements for dogs, in addition to colostrum, contain turmeric, which has anti-inflammatory and antioxidant qualities, making it a popular ingredient.

Final conclusion: providing your pet with colostrum and allergy support chews made from turmeric will not harm him or her, as these supplements do more than only alleviate the symptoms of allergy symptoms.

CBD for Dogs

CBD is an abbreviation for cannabidiol, which is another excellent and natural treatment for canine allergies. Contrary to popular belief, CBD is not produced from cannabis, as many people believe (also known as marijuana). Agricultural hemp is the source of this product. Studies have revealed that CBD may be beneficial in the treatment of itchy and dry skin caused by everyday allergies or severe allergic responses. If your dog ever becomes sick when traveling in the car, CBD may be able to alleviate the symptoms of motion sickness.

If your dog develops an itchy rash, for example, there are CBD balms available that may relieve the itching and calm the sensitive skin on his body.

The Bottom Line on Benadryl for Dogs

There are a plethora of solutions available for dogs that suffer from allergic reactions. As long as you check with your veterinarian and give your dog the proper dosage, Benadryl (or any other brand of diphenhydramine HCL) can be a helpful alternative for canine health, even if it is not the only option for treating allergy symptoms. If you want to learn more about how to naturally support your pet’s allergies, check out PetHonesty’sdelicious and health-conscious supplements, which include all the allergy-fighting elements your dog requires to live a healthy life.

How to use Benadryl to help your dog with allergies, anxiety, and more

  • When given to your dog for allergies, nervousness, motion sickness, or vaccine-related adverse effects, Benadryl is completely safe. Despite the fact that a standard Benadryl tablet has 25 mg, you should only administer 0.9-1.8 mg per pound of body weight to your dog. Inspect the label to ensure that the Benadryl you’re feeding your dog includes solely diphenhydramine. More information may be found in Insider’s Health Reference collection.

Although Benadryl is safe for dogs, it is not recommended that you administer medication to your dog without first visiting a veterinarian since the improper amount might be harmful. Your veterinarian may suggest Benadryl to help treat your dog for illnesses such as hives or nervousness, and he or she may advise you on how to administer the drug in the proper quantity and manner. Here’s all you need to know about how much Benadryl your dog should take and when you should take him to the veterinarian.

Uses of Benadryl for dogs

A common over-the-counter medicine, Benadryl (diphenhydramine), is used to treat itching, swelling, and other allergy-related symptoms such as hives and edema. As a result, you can provide it to your dog under the following situations:

  • A variety of various forms of canine allergies, including food allergies, seasonal allergies, skin allergies, and allergic responses to triggers like as bee stings, can be treated with Benadryl, which is available over-the-counter. It can help to alleviate symptoms such as:
  • Swelling, hives, sneezing, runny nose and eyes, and itchy skin are all possible symptoms.

Veterinary practitioner Terra Price, DVM, MPH, creator of the BlackDVM Network, believes that because sleepiness is a typical side effect of Benadryl, it can be used to temporarily calm agitated dogs. Motion sickness: Because of Benadryl’s sedating effect, it may be beneficial in combating motion sickness during automobile or aircraft flights with your dog. Vaccine reactions: “Puppies receive immunizations early in life, and it is possible that they will have a reaction to these vaccines,” adds Price.

Dosing instructions for Benadryl

It is recommended by theMerck Veterinary Manual to administer 0.9-1.8 mg of Benadryl per pound of body weight (2-4 mg/kg of weight) to your dog. If you wish to experiment with over-the-counter Benadryl, the most effective version is generally a tablet, which has 25 mg of the medication per tablet, according to Dr. Justinine Lee, a board-certified veterinarian who specializes in toxicology and emergency care. This implies that, on average, a 25-pound dog would receive one pill, while a 50-pound dog would receive two pills.

According to Price, veterinarians can also prescribe a canine version of Benadryl called Vetadryl, which is an FDA-approved type of diphenhydramine that is safe to provide to dogs and cats with no side effects.

Despite the fact that it is the same medication and you could theoretically use any of them, Vetadryl offers a number of advantages, including the following:

  • There is a 10 mg alternative, which may make dosage more convenient
  • The addition of dog-friendly flavorings may make it more enticing to your pooch.

Precautions when using Benadryl

Keep the following considerations in mind when using Benadryl:

  • According to Price, “Benadryl is available over-the-counter for pet parents to purchase, but this should only be done under the supervision of a veterinarian.” Your veterinarian can establish the most appropriate starting dose for your dog and evaluate whether Benadryl will have a negative impact with any other drugs he or she is already taking. Lee advises that if you’re buying Benadryl over-the-counter, “you should make sure it’s Benadryl that is solely diphenhydramine and has no additional substances put in,” she adds. Keep an eye out for substances like as acetaminophen or decongestants, which may not be suitable for canines. Always check the expiration date on the Benadryl before giving it to your dog, according to Price, because expired medication can be harmful to your dog.

Side effects of Benadryl in dogs

Some of the most frequently reported adverse effects of Benadryl are as follows:

  • Dry lips, rapid breathing, and inability to urinate are all symptoms of a hypothyroid condition.

“Even though Benadryl is a safe medication, overdose is a possibility,” adds Price. The following are some probable indicators of overdose:

  • Agitation, seizures, dilated pupils, rapid heartbeat, constipation
  • These are only a few of the symptoms.

Agitation, seizures, dilated pupils, rapid pulse, constipation; these are only a few of the side effects.

Insider’s takeaway

If your dog suffers from anxiety, allergies, motion sickness, or any other illness, Benadryl might be a beneficial cure. Although you may purchase Benadryl over-the-counter, it is recommended that you consult with your veterinarian before beginning any new medicine. If your dog exhibits any concerning signs such as seizures or dilated pupils, take him to an emergency veterinarian as soon as possible. The health writer Madeline Kennedy writes for Insider magazine on a variety of health-related issues, such as reproductive and sexual health, mental health issues, nutrition, and infectious diseases.

She graduated from the University of Pennsylvania with a master’s degree in social work and is interested in the nexus of health and social justice.

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